Fibrosis Fibrosis is medically defined as the thickening and scarring of connective tissue. In the context of Chronic Kidney Disease (CKD), it is recognized as the mechanism responsible for the permanent loss of kidney function. Healthy, filtering kidney cells are replaced by non-functional scar tissue through a process driven by chronic inflammation. This scar tissue is incapable of filtering toxins or producing hormones like Erythropoietin. Consequently, the kidneys physically transform from smooth, plump organs into small, firm, and irregular structures. This structural change explains why CKD is considered irreversible. Once the functional tissue is converted to fibrosis, it cannot be restored.
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