Metabolic Acidosis Metabolic Acidosis is a clinical condition characterized by an accumulation of acid in the body's fluids. It is a common complication in later stages of Chronic Kidney Disease (CKD). In a healthy state, the kidneys function as a chemical balancer: they actively excrete hydrogen ions (acid) produced from protein metabolism and reabsorb bicarbonate (a base) to keep the blood neutral. In CKD, this mechanism fails. The compromised kidneys lose the ability to flush out dietary acids and fail to reclaim sufficient bicarbonate. Diagnosis is primarily established through a blood chemistry panel where veterinarians look for a low Total CO2 (TCO2) level, often used as a proxy for bicarbonate, which drops below the normal reference range (typically < 16 mmol/L) as the body uses up its buffers fighting the acid. This acidic state is highly detrimental, causing severe muscle wasting (catabolism) and bone demineralization. It is frequently managed with oral alkalinizing agents, such as potassium citrate, to restore the pH balance.
Disclaimer: This content is for educational purposes only and does not constitute veterinary medical advice. Always consult with your primary care veterinarian or a veterinary internal medicine specialist regarding your cat’s specific condition.