Chronic Kidney Disease (CKD) is defined as the progressive and irreversible loss of metabolic and filtration function in the kidneys that persists for more than three months. It is recognized as the most common metabolic disease affecting geriatric cats. The condition is characterized structurally by the permanent destruction of nephrons, the functional microscopic units of the kidney, which are gradually replaced by non-functional scar tissue known as fibrosis. As this scarring spreads, the kidneys lose their ability to concentrate urine and filter waste products efficiently. This leads to the accumulation of toxins in the blood (azotemia) and an excessive loss of water through the urine (polyuria). Unlike Acute Kidney Injury, CKD cannot be cured or reversed. Instead, the disease is managed over time using the IRIS Staging System to categorize severity. Treatment is focused exclusively on slowing the rate of decline and maintaining quality of life through dietary modification, hydration support, and the management of complications such as hypertension and anemia.
Disclaimer: This content is for educational purposes only and does not constitute veterinary medical advice. Always consult with your primary care veterinarian or a veterinary internal medicine specialist regarding your cat’s specific condition.