Inflammation is defined as the immune system's biological response to harmful stimuli, such as pathogens, damaged cells, or irritants.
While acute inflammation is a healing process (like redness around a cut), in Chronic Kidney Disease (CKD), the problem is "chronic maladaptive inflammation."
In the CKD patient, the kidneys are in a state of constant, low-grade irritation caused by the accumulation of uremic toxins, high blood pressure, and oxidative stress. This persistent alarm bell recruits immune cells to the kidney tissue. Instead of healing the organ, these cells release harsh chemicals called cytokines that damage the delicate filtering units. Over time, this chronic inflammatory fire triggers fibrosis (scarring). The body attempts to "wall off" the damage with scar tissue, but this scar tissue is non-functional and replaces the healthy working kidney tissue. This process drives the relentless progression of the disease. Consequently, therapeutic strategies often include anti-inflammatory supplements, such as Omega-3 fatty acids, to dampen this destructive response and slow the rate of scarring.
Disclaimer: This content is for educational purposes only and does not constitute veterinary medical advice. Always consult with your primary care veterinarian or a veterinary internal medicine specialist regarding your cat’s specific condition.